Buffalo Bills vs Denver Broncos Prediction 1-12-25 NFL Picks

The Denver Broncos and the Buffalo Bills meet Sunday in NFL Wild Card Round playoffs action from Highmark Stadium. Here’s a Buffalo Bills vs Denver Broncos prediction. We will look at this from a betting perspective and determine the best Bills vs Broncos pick.

Denver Broncos Betting Preview

The Broncos opened up the season with a couple of losses, and things weren’t looking good initially. Denver fell to the Seahawks and Steelers in their first pair but found their footing with a 5-1 run over the next six games. The Broncos would lose to only the Chargers during that stretch, otherwise taking wins over the Buccaneers, Jets, Saints, and Panthers. The Broncos would lose consecutive games versus the Ravens and Chiefs but headed into the bye with three straight victories over the Falcons, Raiders, and Browns. Over the last four weeks of the regular season, Denver went 2-2, taking another pair of consecutive losses versus the Chargers and Bengals in between victories over the Colts and Chiefs for a 10-7 overall record.


In their Week 18 game versus the Chiefs, Denver essentially played a game against their opponent’s reserves. The Broncos were able to sleepwalk through that matchup, scoring 24 points in the first half (and putting up points in all four quarters) along the way to a 38-0 blowout defeat. Quarterback Bo Nix finished with 321 yards and four passing touchdowns while also leading the rushing attack with seven carries for 47 yards. Leading the receivers was Courtland Sutton with five grabs for 98 yards and a TD. Marvin Mims caught five balls as well for 51 yards and two touchdowns, while Devaughn Vele posted the other receiving TD.

Buffalo Bills Betting Preview

Over on the Bills’ side, they were able to open up the year with three straight wins. Those came versus the Cardinals, Dolphins, and Jaguars. Following Buffalo’s only pair of consecutive losses this season—versus the Ravens and Texans—the Bills recovered with six straight victories going into the bye week. Those were versus the Jets, Titans, Seahawks, Dolphins, Colts and Chiefs. Since then the Bills have been on a 4-2 run over the final six games of the regular season. Buffalo fell versus the Rams and Patriots in that time with victories otherwise versus the 49ers, Lions, Patriots, and Jets. The result was a solid 13-4 overall record this year.

In the Week 18 matchup versus the rival Patriots, the Bills weren’t able to finish off their regular-season campaign with a victory—but the team was mostly using their reserves as the game hardly mattered. Buffalo was down 17-16 going into the final quarter but ended up losing 23-16 in the end. Mitch Trubisky posted 101 passing yards with a score, while Ray Davis led the rushing attack on 15 carries for 64 yards. Curtis Samuel was the leading team receiver with seven catches for 52 yards, and Keon Coleman registered two grabs for 31 yards.

Why the Buffalo Bills will win

Why the Denver Broncos will win

Total Points Facts

Buffalo Bills Player Prop Facts

Denver Broncos Player Prop Facts

Buffalo Bills vs Denver Broncos Prediction

I’m probably just going to stay with the Bills here. Buffalo didn’t have to do a whole lot versus the Patriots, outside of just getting through the game. The Bills’ stats are reflected in that, as they notched a fairly uncharacteristic 259 total yards (129 passing) and 16 first downs. Buffalo was able to keep a struggling Patriots team in line defensively, however, giving up a modest 19 first downs and 309 total yards. Prior to that matchup, the Bills had scored 30 or more points in nine of their previous 10 games. Buffalo is averaging 30.9 points per game overall this year, with 227.9 yards per game passing (and 30 touchdowns) alongside 131.2 yards per game rushing (and 32 touchdowns.

As for Denver, they’ve overachieved a bit this year and are looking better after a confidence-boosting beatdown of the Chiefs reserves in Week 18. The Broncos have been close in most of their losses this year—only one came by more than a touchdown. That was a 41-10 loss to the Ravens on November 3. Buffalo is capable of putting the Broncos back down though, and I think the Bills will show their stuff at home with a double-digit victory.

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